The main cause of CTE is repetitive traumatic brain injuries. These injuries include concussions and are most commonly su昀昀ered by athletes in contact sports, military veterans, as well as victims of abuse. Consequently, treatment of CTE mostly follows that of standard memory care, such as in patients with Alzheimer’s and other forms of dementia. As de昀椀ned by the American Association of Retired Persons (AARP), memory care provides “a safe, structured environment with set routines to lower stress” in patients. The patient can live independently initially, but as the disease progresses, it is recommended that the patient create a last will as they lose lucidity. By this stage, it is common for partners and children to begin taking care of their loved ones. A昀琀er severe progression of the disease, the recommended course of action includes cognitive behavioral therapy, to treat mood and behavior, and cognitive rehabilitation therapy, to improve cognitive abilities. This caregiving process comes with a whole host of traumas and challenges਀㠀 For example, caregivers must contend with violent and uncharacteristic outbursts, episodes of forgetfulness and delirium, and other challenges, all from a person they love dearly. For the caregiver, it is recommended to streamline daily living for the patient by writing things down for them, developing a permanent Fig 4. by Sacramento Injury Attorneys Blog routine, ensuring adequate sleep and exercise, and maintaining hope. This last tip is particularly prudent, especially when facing the overwhelming and all- encompassing nature of the disease. Patience is Beyond the clinical landscape, CTE has made a o昀琀entimes the 昀椀rst thing to go in this relationship਀㠀 tremendous impact on sports leagues such as the NFL. Such a strong relationship between this disease and Current CTE treatments are limited. Other than the football proved to be extremely controversial for the therapies discussed above, there are no medicines that league. Even before CTE had made its way to can reverse CTE progression. Therapeutics are few American headlines, scientists a昀케liated with the NFL and far between. A few companies claim to be making demanded Dr. Bennet Omalu—a pioneer in CTE progress on the matter, such as “Therapeutic Solutions research—retract one of his 昀椀rst papers that linked International, Inc.,” which aims to bring stem cell CTE with contact sports. The NFL’s denial of the link therapy to CTE patients. There are even addiction between football and CTE extended to at least 2016.਀ꨀ centers that claim to provide “NAD/NADH” therapy to patients. In both cases, these claims are not supported Among NFL players, some have criticized the by any reputable academic or governmental body, organization itself. Others have even gone on record underscoring how sparse this area of research is㠀᐀ stating that they would never let their children or grandchildren play the sport. One such player, New York Giants Hall of Fame linebacker Harry Carson, stated: “But I don't want him [my grandchild] to play football, because I think this young, smart black kid, I want him to be intelligent; I want him to be brilliant; I want him to be able to use his brain and not his brawn.” He later states that he regrets playing football entirely, a sentiment that is shared by many other players in the NFL਀㠀 In conclusion, CTE stands as a nebulous and enigmatic disease. Distinctive in its unique origin— primarily stemming from injury in human physical activity—it di昀昀erentiates itself from other neurodegenerative diseases more closely linked with genetic predispositions or environmental factors. Constrained resources, therapy, and clinical research in CTE have collectively upended an entire industry, underscoring the critical need for increased attention to better understand and treat this complex issue. Someday, the frontier of science will uncover critical truths surrounding CTE, granting those who su昀昀er from the disease a new chance at life. Until then, however, it remains a scienti昀椀c puzzle, urging us to persist in our quest for knowledge.ꀀ਀ Fig. 3 by Tedhyman Images 8