controversies led to the nutritional condition. As a result, there is significant variation in hGH establishment of anti-doping secretion internally and cross comparatively between athletes. Due to it agencies and policies to prevent being difficult to detect, hGH has become one of the most controversial similar incidents in the future㠀 PEDs in the modern era㠀 The 2003 Bay Area Laboratory Co-Operative (BALCO) Scandal exposed a Current State of Anti- network of athletes, coaches, and suppliers involved in doping practices. Doping Measure猀 Balco had provided hGH to several prominent American athletes, including To combat the ongoing challenge Marion Jones and Tim Montgomery. This was revealed following a raid on of PEDs, the World Anti-Doping BALCO's Agency (WADA) was established in offices on ... many of these substances can have 1999 [5]. WADA plays a central role September 3, “ serious, long-term consequences for in setting global anti-doping 2003, when standards, conducting tests and athletes, such as ‘hematologic, cardio- proof of implementing sanctions. For systematic vascular, psychiatric and neuro- instance, WADA’s Athlete Biological doping was Passport initiative strictly monitors psychological, and hormonal and discovered, changes in an athlete's blood implicating metabolic effects’ [11崀 profile, making it harder for numerous athletes to manipulate their ” high-profile figures in American The Ethical Dilemm愀 physiological parameters to hide football, baseball, and athletics [7, The use of PEDs in sports raises doping. Anti-doping measures have 8]. This investigation highlighted critical ethical concerns, as it also become more stringent, with the persistence of doping and challenges the notion of fair lifetime bans and the forfeiture of prompted concerns about the competition, because athletes who medals as potential consequences credibility of athletic achievements 8 use PEDs gain an unfair advantage for athletes found guilty of using over their competitors. Moreover, these PEDs㠀 High-Profile Cases and the health risks associated with Their Impac琀 PEDs are a major concern, as many The Modern Doping Numerous high-profile cases have of these substances can have Landscap攀 exposed the pervasive nature of serious, long-term consequences The 21st century has seen the PED use in sports. One of the most for athletes, such as hematologic, emergence of more sophisticated infamous cases involved Lance cardiovascular, psychiatric and and elusive performance- Armstrong, a seven-time Tour de neuropsychological, and hormonal enhancing substances. Athletes France champion. In 2012, and metabolic effects” [11]㠀 have turned to substances such as Armstrong admitted to using PEDs growth hormone, erythropoietin throughout his career. In 2015, Conclusio渀 (EPO), and designer steroids, Russia faced allegations of state- The history of PEDs in sports is which are harder to detect and sponsored doping, which led to a riddled with controversies and offer significant performance widespread ban of Russian ethical dilemmas. From the early advantages. Human growth athletes from international use of stimulants in ancient Greece hormone (hGH) is a peptide that competitions [9]. The scandal to the emergence of state- has a brief blood half-life and a low sparked controversies and raised sponsored doping programs and urine concentration. The primary questions about the extent of modern sophisticated substances, 22 kDa isoform released by the doping in professional sports and PEDs have significantly impacted pituitary gland shares the same the integrity of international the world of sports. The efforts of sequence of amino acids as the competitions. More recently, in anti-doping agencies like WADA recombinant manufactured version. 2022, WNBA star Brittney Griner have made strides in curbing PED A post-transcriptional change of faced a high-profile detainment for use, but high-profile cases and the molecule cannot be used to cannabis possession, a banned evolving substances continue to discern the differences between WADA substance, raising questions test their integrity. Striking a the recombinant and natural forms about the effectiveness of anti- balance between fair competition [6]. Furthermore, hGH is a stress doping policies and the regulation and athlete health remains a hormone that is influenced by a of substances deemed legal in complex issue, with no clear number of variables, including certain jurisdictions, but not in solution㠀᐀ mood, sleep, physical activity, and athletics [10]㠀 36
Penn Healthcare Review Fall 2023 Journal— Sports Medicine Page 40 Page 42